Al-Ghunaim is a pivotal figure in Arab and Kuwaiti banking and finance. In 1998, she founded Global Investment House, one of the most renowned companies in the Arab World. She is well-known for taking the company international and onto the London Stock Exchange in 2008, making it the first Kuwaiti company to be listed there. In 2018, GIH was acquired by Kamco Investment. Al-Ghunaim continues to serve on several boards and remains a highly influential figure in the regional financial sector.