Saifuddin is the 53rd Dai Al-Mutlaq (Unrestricted Missionary) of the Dawoodi Bohras, a subgroup within the Mustaali, Ismaili Shia branch of Islam. He succeeded—but not without dispute—to the office after his father, Syed Mohammed Burhanuddin, passed away in 2014. In 2017, he inaugurated the 14-acre Nairobi campus of Aljamea-tus-Saifiyah, a Dawoodi Bohra institute of higher learning. Kenyan President Kenyatta awarded him the Elder of the Order of the Golden Heart as a result. He also met Egyptian President El-Sisi in 2016 and donated 10 million EGP to the Long Live Egypt fund. He is the spiritual leader of 2-5 million people living in 100 countries.