Dr Al-Issa was appointed secretary-general of the Muslim World League in 2016. Prior to that he had served as Minister of Justice and Head of the Supreme Council for Justice. The Muslim World League is an NGO which was founded in 1962 and is based in Makkah. It propagates Saudi teachings worldwide as well as carrying out social work. Al-Issa visited the Vatican in 2017 where he met the Pope and in 2020 led a delegation of Islamic scholars to visit Srebrenica in Bosnia, and Auschwitz concentration camp in Poland.