Al-Zindani is an active Yemeni politician and preacher. He is the founder of Iman University in Yemen, the Founder of the Commission on Scientific Signs in the Qur’an and Sunnah in Makkah, the Chairman of the Shura Council of the Islah party (the Yemeni Congregation for Reform), and the Head of the Muslim Brotherhood in Yemen. He has been a vocal critic of terrorism and any killing of civilians. At the same time, he is an outspoken critic of US policies, declaring that jihad against any army that invades Yemen is self-defence and is the right of its citizens. The US Treasury labelled him a Specially Designated Global Terrorist (SDGT) for his indirect association with Al-Qaeda. In 2020 he moved from Saudi Arabia to Türkiye.